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DeCS
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Descriptor English:
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Autophagy-Related Protein-1 Homolog
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Descriptor Spanish:
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Homólogo de la Proteína 1 Relacionada con la Autofagia
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Descriptor Portuguese:
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Proteína Homóloga à Proteína-1 Relacionada à Autofagia
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Synonyms English:
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Serine-Threonine Protein Kinase ULK1
ULK1 Protein
Unc-51 Like Autophagy Activating Kinase 1
Unc-51-Like Kinase 1
Autophagy Related Protein 1 Homolog
Serine Threonine Protein Kinase ULK1
Unc 51 Like Autophagy Activating Kinase 1
Unc 51 Like Kinase 1
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Tree Number:
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D08.811.913.696.620.682.700.108
D12.644.360.081
D12.776.094.438
D12.776.476.078
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Definition English:
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A serine/threonine-protein kinase that functions in AUTOPHAGY in response to starvation. It acts on the PHOSPHATIDYLINOSITOL 3-KINASE complex PIK3C3 to regulate AUTOPHAGOSOME formation. It also functions as both a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) and is activated by AMPK, which it also negatively regulates. |
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History Note English:
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2017
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Allowable Qualifiers English:
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Record Number:
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56509
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Unique Identifier:
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D000071189
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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